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R-ketamine (arketamine) is the other mirror-image form (enantiomer) of ketamine. Unlike S-ketamine (esketamine), it is still investigational and is not widely approved as a prescription medication.
Although research is ongoing, reported side effects may include:
| Feature | R-ketamine (Arketamine) | S-ketamine (Esketamine) |
|---|---|---|
| Approval status | Investigational | Approved in some countries for certain forms of depression |
| Research | Early clinical studies | Extensive clinical evidence |
| Antidepressant effects | Promising but not yet confirmed | Well established for approved uses |
| Dissociative effects | May be less pronounced (preliminary evidence) | More common |
| Clinical availability | Limited to research settings | Available by prescription in eligible patients |



